Potent in vitro activity of the albumin fusion type 1 interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agents of bioterrorism and the severe acute respiratory syndrome (SARS) virus.
Identifieur interne : 003056 ( Main/Exploration ); précédent : 003055; suivant : 003057Potent in vitro activity of the albumin fusion type 1 interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agents of bioterrorism and the severe acute respiratory syndrome (SARS) virus.
Auteurs : G Mani Subramanian [États-Unis] ; Paul A. Moore ; Brian B. Gowen ; Aaron L. Olsen ; Dale L. Barnard ; Jason Paragas ; Robert J. Hogan ; Robert W. SidwellSource :
- Chemotherapy [ 1421-9794 ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (pharmacologie), Bioterrorisme, Ebolavirus (), Ebolavirus (physiologie), Interféron alpha (pharmacologie), Interféron bêta (pharmacologie), Interféron de type I (pharmacologie), Lignée cellulaire, Protéines de fusion recombinantes (pharmacologie), Protéines recombinantes, Réplication virale (), Virus du SRAS (), Virus du SRAS (physiologie).
- MESH :
- pharmacologie : Antiviraux, Interféron alpha, Interféron bêta, Interféron de type I, Protéines de fusion recombinantes.
- physiologie : Ebolavirus, Virus du SRAS.
- Animaux, Bioterrorisme, Ebolavirus, Lignée cellulaire, Protéines recombinantes, Réplication virale, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Bioterrorism, Cell Line, Chlorocebus aethiops, Ebolavirus (drug effects), Ebolavirus (physiology), Interferon Type I (pharmacology), Interferon-alpha (pharmacology), Interferon-beta (pharmacology), Recombinant Fusion Proteins (pharmacology), Recombinant Proteins, SARS Virus (drug effects), SARS Virus (physiology), Virus Replication (drug effects).
- MESH :
- chemical , pharmacology : Antiviral Agents, Interferon Type I, Interferon-alpha, Interferon-beta, Recombinant Fusion Proteins.
- drug effects : Ebolavirus, SARS Virus, Virus Replication.
- physiology : Ebolavirus, SARS Virus.
- Animals, Bioterrorism, Cell Line, Chlorocebus aethiops, Recombinant Proteins.
Abstract
The type 1 interferons (INF-alpha and INF-beta) are potent antiviral agents. Albumin-INF-alpha and albumin-INF-beta are novel recombinant proteins consisting of IFN-alpha or IFN-beta genetically fused to human albumin.
DOI: 10.1159/000140361
PubMed: 18560223
Affiliations:
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Le document en format XML
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